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| Don Cheadle | Montel Gordon | |
| Michael Douglas | Robert Hudson Wakefield | |
| Benicio Del Toro | Javier Rodriguez Rodriguez | |
| Erika Christensen | Caroline Wakefield | |
| Dennis Quaid | Arnie Metzger | |
| Catherine Zeta-Jones | Helena Ayala | |
| Jacob Vargas | Manolo Sanchez | |
| Michael O'Neill | Lawyer Rodman | |
| Steven Bauer | Carlos Ayala | |
| Benjamin Bratt | Juan Obregon | |
| Andrew Chavez | Desert Truck Driver | |
| Michael Saucedo | Desert Truck Driver | |
| Tomas Milian | General Arturo Salazar | |
| Jose Yenque | Salazar Soldier / Torturer | |
| Russell G. Jones | Mark |
| Director |
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| Producer | Edward Zwick
Mike Newell |
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| Writer | Stephen Gaghan
Simon Moore |
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The movie takes a broad approach to the war on drugs in the USA. It shows the corruption in both Mexico and the USA. Both on a personnal scale as on larger scale. The movie has a lot of storylines, which are tied together slowly. |
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